期刊： JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 2021; 377 (2)
Bariatric surgery is the most common and effective treatment of severe obesity; however, these bariatric procedures always result in detrimental effec......
期刊： JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 2021; 377 (3)
Recently, circular RNA was reported to be a significant participant in the development of tumorigenesis, including colorectal cancer. Therefore, we ai......
期刊： JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 2021; 378 (1)
TPN672 [7-(2-(4-(benzothiophen-4-yl) piperazin-1-yl)ethyl)quinolin-2(1H)-one maleate] is a novel antipsychotic candidate with high affinity for seroto......
期刊： JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 2021; 377 (2)
Alzheimer's disease (AD) is a neurodegenerative disease with complex pathologic and biologic characteristics. Extracellular beta-amyloid deposits, suc......
期刊： JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 2021; 376 (2)
G protein-coupled estrogen receptor (GPER) might be involved in ulcerative colitis (UC), but the direct effect of GPER on UC is still unclear. We used......
期刊： JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 2021; 377 (1)
Insulin resistance (IR) is the common basis of diabetes and cardiovascular diseases, and its development is closely associated with lipid metabolism d......
期刊： JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 2021; 377 (3)
Understanding pharmacokinetic (PK)-pharmacodynamic (PD) relationships is essential in translational research. Existing PK-PD models for combination th......
期刊： JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 2021; 377 (3)
Ca2+/calmodulin-dependent protein kinase II (CaMKII) is upregulated in congestive heart failure (CHF), contributing to electrical, structural, and fun......
期刊： JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 2021; 376 (3)
Chronic pain is a public health problem because current treatments are unsatisfactory with small therapeutic index. Although pregabalin is effective f......
期刊： JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 2021; 376 (3)
Recent studies suggest an important role for RNA, especially noncoding RNA, in inflammatory bowel disease (IBD) and colon cancer. Drug development bas......
期刊： JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 2021; 377 (1)
Intracerebral hemorrhage (ICH) is a devastating disease with the high mortality. The poor outcome of ICH is partially due to a combination of various ......
期刊： JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 2021; 377 (1)
Treatment of chronic pain remains an unmet medical need. The neuronal voltage-gated potassium Kv7/KCNQ/M channel has been implicated as a therapeutic ......
期刊： JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 2021; 376 (1)
Immune checkpoint inhibitors have emerged as a frontline treatment of a variety of malignancies. However, only a subset of patients respond to these t......
期刊： JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 2020; 374 (1)
Nonalcoholic fatty liver disease is a chronic inflammatory liver disease. It is associated with obesity and type 2 diabetes. Oxycholesterols are metab......
期刊： JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 2020; 375 (3)
Halogenated tyrosine/phenylalanine derivatives have been developed for use in tumor imaging and targeted alpha therapy. 3-Fluoro-alpha-methyl-L-tyrosi......
