Allergy Asthma Immunol Res:儿童特应性皮炎患病率随年龄增加的变化趋势

2022-02-25 医路坦克 MedSci原创

特应性皮炎(AD)是一种复杂的多因素皮肤病,该研究发现儿童AD年患病率的时间趋势因年龄段不同而不同,AD在婴儿期的发病率正在减少,而晚发性AD或早发性持续性AD的表型可能会增加。

    特应性皮炎(AD)是一种复杂的多因素皮肤病,具有相当大的表型异质性。根据最近的研究,存在不同的临床和免疫学特征的表型,因此它们表现出不同的疾病过程。为了正确管理AD,应根据不同的AD表型采取适当的预防和治疗策略为了评估这些策略在特定地区或社会是否有效,有必要定期监测AD的患病率。

    在韩国使用国际儿童哮喘和过敏症研究(ISAC)问卷进行的全国人群流行病学调查显示,6-7岁和12-13岁儿童的“最近12个月内湿疹治疗”的患病率分别从2000年的11.9%上升到2010年的15.3%和从2000年的7.4%上升到2010年的8.9%。韩国国家医疗保险局(NHIS)的数据显示,6-18岁儿童和青少年中AD的估计患病率低于问卷调查。考虑到有些患者接受替代药物或无法获得医疗服务,基于NHIS数据的AD患病率极有可能被低估。尽管NHIS数据的诊断准确性存在争议,但这些数据的估计患病率可以用来观察随着时间的变化,因为它们不仅来自整个人口,而且是以一致的方式估计的。

    本研究旨在探讨韩国儿童特应性皮炎(AD)患病率随年龄变化的增减趋势。我们使用韩国国家健康保险服务(NHIS)和韩国统计局(Statistics Korea)的数据观察了2003至2018年间估计的AD年患病率的变化。每年以12~23个月龄儿童患病率最高,以后随年龄增长患病率下降。韩国18岁以下儿童AD的年患病率从2003年的4.0%微升至2018年的4.5%。在此期间,6至18岁儿童的患病率从2003年的1.9%上升到2018年的3.1%,而24个月以下婴儿的患病率大幅下降。在1991年、1997年、2000年、2003年和2006年出生的儿童中,6岁以上的下降趋势线的斜率相似。将2009年和2012年出生的儿童与2006年以前出生的儿童进行比较,出生年份越近,6岁以上儿童AD患病率越高。

   综上所述,2003-2018年韩国儿童AD年患病率的时间趋势因年龄段不同而不同。这些结果表明,AD在婴儿期的发病率正在减少,而晚发性AD或早发性持续性AD的表型可能会增加。为了更有效地预防和治疗儿童的AD,需要根据年龄采取不同的策略。

文献来源:Lee JY,  Kim J,  Ahn K,Time Trends in the Prevalence of Atopic Dermatitis in Korean Children According to Age.Allergy Asthma Immunol Res 2022 Jan;14(1)

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    2022-04-05 skhzy

    #asthma#

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    2022-03-22 ms24272190615788285182

    #AST#

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    2022-02-23 xinmeili

    #患病率#

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    2022-02-23 膀胱癌

    #ALL#

    0

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