Lancet子刊:西安交大:中老年人肌肉减少或导致心血管疾病风险激增!

2022-01-20 MedSci原创 MedSci原创

肌少症可能与中国中老年人的高心血管疾病风险有关。

肌肉减少症是一种严重的老年综合症,表现为骨骼肌肉质量下降,加上肌肉力量低下,及/或体能低下,是老龄化社会面临的公共卫生问题。在过去十年,多项研究报告指出,在亚洲地区的老年人中,"肌肉减少症 "的发病率由6.8%至25.7%不等。

年龄的增长是与心血管疾病(CVD)发展相关的最强风险因素,是老年患者死亡的主要原因之一。最近,越来越多的研究探讨了肌少症与CVD之间的关系,如冠心病、心房颤动、心力衰竭和中风。

目前对中国人群中老年人肌少症与CVD之间的关系知之甚少。为此,来自西安交大附属医院的专家利用中国健康与退休纵向研究(CHARLS)中具有全国代表性的数据,进行了横断面和纵向分析,以研究中国中老年人群中肌肉疏松症状态与心血管疾病之间的关系。结果发表在《柳叶刀》子刊EclinicalMedicine杂志上。

该样本包括15137名年龄在45岁以上的CHARLS 2015的参与者。肌少症状态是根据2019年亚洲肌少症工作组(AWGS 2019)的标准来定义的。CVD为存在医生诊断的心脏病和/或中风。从CHARLS 2015中共招募了11863名无CVD的参与者,并在2018年进行了随访。进行了Cox比例危害回归模型,研究了肌少症对心血管的影响。

在总体人群中,无肌少症、可能的肌少症和肌少症患者的CVD患病率分别为12.6%(1905/15137)、10.0%(1026/10280)、18.1%(668/3685)、18.0%(211/1172)。在总人群中,可能的肌少症[OR(95%CI):1.29(1.13-1.48)]和肌肉疏松症[1.72(1.40-2.10)]分别与CVD风险增加29%和72%有关。

2015-2018年,基线肌少症状态与新发生CVD的纵向关联。

在3.6年的随访中,确定了1273例(10.7%)发生CVD的病例。在纵向分析中,被诊断为可能患有肌少症的人(HR=1.22,95% CI:1.05-1.43)和肌少参与者(HR:1.33,95% CI:1.04-1.71)比没有肌少症的同龄人新发CVD的风险增加22%与33%。

综上,使用2019年AWGS标准评估的"肌少症 "可能与中国中老年人的高心血管疾病风险有关。

 

参考文献:

Association between sarcopenia and cardiovascular disease among middle-aged and older adults: Findings from the China health and retirement longitudinal study. DOI:https://doi.org/10.1016/j.eclinm.2021.101264

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    2022-02-18 more is better!

    #中老年#

    0

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    2022-12-21 howi

    #Lancet#

    0

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    2022-07-22 gjsgj
  5. [GetPortalCommentsPageByObjectIdResponse(id=1923816, encodeId=e0aa1923816f2, content=<a href='/topic/show?id=56a522389f9' target=_blank style='color:#2F92EE;'>#中老年#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=97, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=22389, encryptionId=56a522389f9, topicName=中老年)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ca6a2500099, createdName=more is better!, createdTime=Fri Feb 18 16:49:39 CST 2022, time=2022-02-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1831441, encodeId=03ca183144151, content=<a href='/topic/show?id=1b6210686b2' target=_blank style='color:#2F92EE;'>#Lancet#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10686, encryptionId=1b6210686b2, topicName=Lancet)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3f0227, createdName=howi, createdTime=Wed Dec 21 05:49:39 CST 2022, time=2022-12-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1985581, encodeId=6c861985581a9, content=<a href='/topic/show?id=7f68904898a' target=_blank style='color:#2F92EE;'>#西安交大#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=90489, encryptionId=7f68904898a, topicName=西安交大)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3fc52500170, createdName=12498cbcm00(暂无昵称), createdTime=Fri Oct 21 14:49:39 CST 2022, time=2022-10-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1771328, encodeId=27af1e7132837, content=<a href='/topic/show?id=9ced223904c' target=_blank style='color:#2F92EE;'>#中老年人#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=22390, encryptionId=9ced223904c, topicName=中老年人)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=71df38244151, createdName=gjsgj, createdTime=Fri Jul 22 04:49:39 CST 2022, time=2022-07-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1647113, encodeId=2008164e113fb, content=<a href='/topic/show?id=fd6d809e535' target=_blank style='color:#2F92EE;'>#肌肉减少#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=80975, encryptionId=fd6d809e535, topicName=肌肉减少)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d18723374958, createdName=shizhenshan, createdTime=Sat Feb 12 23:49:39 CST 2022, time=2022-02-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1764291, encodeId=83591e642917c, content=<a href='/topic/show?id=967b66e9727' target=_blank style='color:#2F92EE;'>#激增#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=66797, encryptionId=967b66e9727, topicName=激增)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=faa237702659, createdName=ms1756883563247400, createdTime=Wed Apr 06 15:49:39 CST 2022, time=2022-04-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1473310, encodeId=8a4b14e331028, content=<a href='/topic/show?id=862be0746bc' target=_blank style='color:#2F92EE;'>#疾病风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=70746, encryptionId=862be0746bc, topicName=疾病风险)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3c757221906, createdName=花花1368, createdTime=Fri Jan 21 12:49:39 CST 2022, time=2022-01-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1499003, encodeId=bf52149900322, content=<a href='/topic/show?id=bb6f89e145a' target=_blank style='color:#2F92EE;'>#血管疾病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89714, encryptionId=bb6f89e145a, topicName=血管疾病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ccb99370406, createdName=andy2090, createdTime=Fri Jan 21 12:49:39 CST 2022, time=2022-01-21, status=1, ipAttribution=)]
    2022-02-12 shizhenshan
  6. [GetPortalCommentsPageByObjectIdResponse(id=1923816, encodeId=e0aa1923816f2, content=<a href='/topic/show?id=56a522389f9' target=_blank style='color:#2F92EE;'>#中老年#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=97, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=22389, encryptionId=56a522389f9, topicName=中老年)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=ca6a2500099, createdName=more is better!, createdTime=Fri Feb 18 16:49:39 CST 2022, time=2022-02-18, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1831441, encodeId=03ca183144151, content=<a href='/topic/show?id=1b6210686b2' target=_blank style='color:#2F92EE;'>#Lancet#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=54, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=10686, encryptionId=1b6210686b2, topicName=Lancet)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3f0227, createdName=howi, createdTime=Wed Dec 21 05:49:39 CST 2022, time=2022-12-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1985581, encodeId=6c861985581a9, content=<a href='/topic/show?id=7f68904898a' target=_blank style='color:#2F92EE;'>#西安交大#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=80, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=90489, encryptionId=7f68904898a, topicName=西安交大)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3fc52500170, createdName=12498cbcm00(暂无昵称), createdTime=Fri Oct 21 14:49:39 CST 2022, time=2022-10-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1771328, encodeId=27af1e7132837, content=<a href='/topic/show?id=9ced223904c' target=_blank style='color:#2F92EE;'>#中老年人#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=78, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=22390, encryptionId=9ced223904c, topicName=中老年人)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=71df38244151, createdName=gjsgj, createdTime=Fri Jul 22 04:49:39 CST 2022, time=2022-07-22, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1647113, encodeId=2008164e113fb, content=<a href='/topic/show?id=fd6d809e535' target=_blank style='color:#2F92EE;'>#肌肉减少#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=70, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=80975, encryptionId=fd6d809e535, topicName=肌肉减少)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=d18723374958, createdName=shizhenshan, createdTime=Sat Feb 12 23:49:39 CST 2022, time=2022-02-12, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1764291, encodeId=83591e642917c, content=<a href='/topic/show?id=967b66e9727' target=_blank style='color:#2F92EE;'>#激增#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=60, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=66797, encryptionId=967b66e9727, topicName=激增)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=faa237702659, createdName=ms1756883563247400, createdTime=Wed Apr 06 15:49:39 CST 2022, time=2022-04-06, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1473310, encodeId=8a4b14e331028, content=<a href='/topic/show?id=862be0746bc' target=_blank style='color:#2F92EE;'>#疾病风险#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=67, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=70746, encryptionId=862be0746bc, topicName=疾病风险)], attachment=null, authenticateStatus=null, createdAvatar=, createdBy=3c757221906, createdName=花花1368, createdTime=Fri Jan 21 12:49:39 CST 2022, time=2022-01-21, status=1, ipAttribution=), GetPortalCommentsPageByObjectIdResponse(id=1499003, encodeId=bf52149900322, content=<a href='/topic/show?id=bb6f89e145a' target=_blank style='color:#2F92EE;'>#血管疾病#</a>, beContent=null, objectType=article, channel=null, level=null, likeNumber=64, replyNumber=0, topicName=null, topicId=null, topicList=[TopicDto(id=89714, encryptionId=bb6f89e145a, topicName=血管疾病)], attachment=null, authenticateStatus=null, createdAvatar=null, createdBy=ccb99370406, createdName=andy2090, createdTime=Fri Jan 21 12:49:39 CST 2022, time=2022-01-21, status=1, ipAttribution=)]
    2022-04-06 ms1756883563247400

    #激增#

    0

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    2022-01-21 花花1368
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    2022-01-21 andy2090

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