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Viruses：巴西Samba病毒的微观特征

2017-03-30 MedSci MedSci原创

Samba病毒冷冻结构

Samba的初步表征揭示了一些结构信息，尽管使用的制备技术很容易产生结构伪像。为了为Samba产生更多的真实结构信息，研究人员通过低温电子显微镜，低温电子断层扫描，扫描电子显微镜和荧光显微镜分析了病毒。这些显微镜技术证明Samba颗粒的衣壳直径为〜527nm，纤维长度为〜155nm，使Samba成为最大的拟病毒。研究人员还将Samba与无纤维模拟病毒变体进行了比较。Samba颗粒与模拟病毒不同，似

最近，来自密歇根州立大学（MSU）生物化学与分子生物学系的科学家们利用低温电子显微镜研究了巴西巨型桑巴病毒，相关研究刊登于国际杂志Viruses上。

在2003年发现拟病毒之前，病毒一直被认为是很小，仅仅具有简单基因结构。拟病毒的出现粉碎了这些传统概念，改变了对病毒的认识。它具有〜750 nm粒径，并且其基因组为〜1.2 Mbp。自从发现以来，巨型病毒的分离和特征的报道已经很多。最近发现的巨型病毒之一是Samba病毒，是从巴西亚马逊的Rio Negro分离的一种拟病毒。

Samba的初步表征揭示了一些结构信息，尽管使用的制备技术很容易产生结构伪像。为了为Samba产生更多的真实结构信息，研究人员通过低温电子显微镜，低温电子断层扫描，扫描电子显微镜和荧光显微镜分析了病毒。这些显微镜技术证明Samba颗粒的衣壳直径为〜527nm，纤维长度为〜155nm，使Samba成为最大的拟病毒。研究人员还将Samba与无纤维模拟病毒变体进行了比较。Samba颗粒与模拟病毒不同，似乎不是刚性的和准二十面体的，研究发现这两种病毒具有许多共同的特征，包括在拟病毒中可能是常见的多层衣壳和不对称核衣壳。

原始出处：

Jason R. Schrad , Eric J. Young , Jônatas S. Abrahão. et al. Microscopic Characterization of the Brazilian Giant Samba Virus. Viruses 2017, 9(2), 30; doi:10.3390/v9020030

本文系梅斯医学（MedSci）原创编译整理，转载需授权！

评论区 (3)
#插入话题
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    2017-03-31 sunrural_42825361

    #virus#

    0

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    2017-03-31 dongjia2015

    #SES#

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    2017-03-31 ms9833124466084992

    #巴西#

    0